Independent computational biology · Vienna

Leave with more than results — leave with capability.

I work with small biotechs to extend the computational capabilities behind their science, rather than outsourcing the thinking. Quick answers when that's all you need; durable capability your team can own when that's what moves the needle.

25+
Years in biotech R&D
PhD
Genetics · University of Vienna
1-on-1
Direct work, no agency layer
EU · NDA
Vienna-based, NDA-ready
What I do

Five domains, one collaborator.

From rational protein engineering to AI-driven de-novo design — and the cloud infrastructure to run it at scale. I take projects end-to-end or plug into your team where you need depth.

01 / Protein

Protein, peptide & de-novo design

Rational engineering of mutants, fusions and fragments — solubility, stability, glycosylation, IP position. Increasingly built around AI methods: AlphaFold, RFdiffusion, ProteinMPNN, ESM-based scoring.

  • Variant & fusion design
  • De novo binders
  • Epitope & antigen engineering
  • Developability assessment
02 / mRNA & Vaccines

Vaccine & mRNA platform engineering

Reverse vaccinology pipelines, antigen and epitope selection, HLA and strain coverage, population centroid design. Tissue-specific bicodon optimization and UTR selection for proprietary mRNA platforms.

  • Computational vaccinology
  • T-cell & B-cell epitope prediction
  • Codon & UTR optimization
  • Cross-strain antigen design
03 / AI & ML

Custom AI & ML for biology

Bespoke model development where off-the-shelf tools fall short — from fine-tuning protein language models to building scoring functions, prediction pipelines and agentic workflows around your data.

  • Protein language models
  • Custom scoring & ranking
  • LLM/agentic R&D workflows
  • Benchmarking & validation
04 / Data & Cloud

Data integration & AWS infrastructure

Heterogeneous biomedical data — PubMed, MeSH, drug and target databases, patent full-text — woven into queryable graphs and pipelines. Optional setup of reproducible AWS environments for compute-heavy work.

  • Bio-data warehousing
  • Knowledge graphs
  • Reproducible pipelines
  • AWS / GPU compute setup
05 / Strategy & IP

Strategic consulting, IP & reviews

Translating bioinformatic results into biomedical decisions. IP background and freedom-to-operate searches, custom literature reviews, drug repositioning via protein/drug/disease networks.

  • Decision support
  • Literature & IP landscape
  • Drug repositioning
  • Method scope & utility advice
06 / Scoped project

Start with a small, scoped engagement.

A specific question, a few days, a concrete deliverable — a low-stakes way to see how we work together before any larger commitment. Even a short engagement is done transparently and documented: nothing is a black box. You can take the process in-house if and when it makes sense for you, or just take the result; both are fine.

  • Defined scope
  • Fixed budget
  • Concrete deliverable
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Why capability matters

Your platform is worth more than its outputs.

Outsource everything and you own the output and nothing else — and you start from zero on the next program. Extend your own capability and every project after the first is faster, the expertise stays in your team, and you're not dependent on anyone to run your own science. Investors notice the difference too: owned capability reads as a defensible platform, not a one-off result.

  • Not everything belongs in-house. A one-off question or a commodity step is often cheaper to simply buy. The skill is knowing which is which — I'll help you build what compounds and is core to your edge, and point you elsewhere for the rest.
How I work

What you can count on.

Domain & methods

Twenty-five years in pre-clinical biotech across infectious disease, oncology, mRNA, antigen design and drug repositioning.

Modern AI, used honestly

AlphaFold, RFdiffusion, ProteinMPNN, ESM, and bespoke models — paired with classical structural and statistical methods where they outperform.

Direct collaboration

You work with me, not with an account manager. NDAs welcome, IP stays with you, no offshore subcontracting.

Honest scoping

If a project is better done in-house, with a different vendor, or with a wet-lab partner first, I'll say so.

Dr. Johannes Söllner

Molecular geneticist (PhD, University of Vienna). 25+ years across startups and established biotech — protein, peptide and RNA engineering, computational vaccinology, and AI-driven de-novo protein design. Former Associate Director at BioNTech R&D Austria (2023–2025).

  • PhD, Molecular Genetics Univ. Vienna
  • Assoc. Director, BioNTech 2023–2025
  • Founded Sodatana e.U. 2013
  • Vienna · Austria · EU Base
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A note from me

Twenty years in — and the field has never been more interesting.

When I started, “bioinformatics” meant BLAST searches, hand-curated motifs and a lot of waiting on jobs. Today, I can sketch a binder geometry in the morning, generate sequences with diffusion models by noon, and have folded structures by afternoon. The fundamentals — biology, careful evaluation, knowing what a result actually means — matter more than ever.

Sodatana is how I bring that combination — deep domain knowledge plus current AI craft — to projects that need it. If that sounds like yours, let's talk.

Ready to start?

Let's scope your project.

A short call usually clarifies what's possible, what the realistic timeline is, and whether a small pilot or a full engagement makes more sense. No obligation, no sales pitch.